Amazon Studios has revealed a new trailer for the upcoming drama filmLife Itself, written and directed byDan Fogelman, who’s found great success on the small screen with the hit NBC seriesThis Is Us. The film tells the love story of a couple played byOscar IsaacandOlivia Wilde, told through multiple generations and spanning both decades and continents. This trailer certainly teases a sweeping, romantic story anchored by Isaac and Wilde, but there are also possibly hints at aThis Is Us-like twist if I’m reading this thing right.

Fogelman’s early feature credits were for writing family films likeBolt,Tangled, andCars 2, but he broke out in a big way with writing 2011’s romantic comedyCrazy, Stupid, Love.After that, he went on to create two semi-successful TV series:The NeighborsandGalavant.Life Itselfmarks his return to the big screen after gettingThis Is Usoff the ground, and I have to say the marketing for this in terms of aiming at theThis Is Usaudience is very on point.

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This is the kind of movie that really could go either way. There’s always the worry that you’re in for aCollateral Beauty-like disaster with something this emotionally raw, but there’s also the chance you get something likeJerry Maguire. We’ll find out this fall.

Check out theLife Itselftrailer below. The film also starsMandy Patinkin,Olivia Cooke,Laia Costa,Annette Bening, andAntonio Banderas.Life Itselfopens in theaters on September 21st.

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Here’s the official synopsis forLife Itself:

As a young New York couple goes from college romance to marriage and the birth of their first child, the unexpected twists of their journey create reverberations that echo over continents and through lifetimes in Life Itself. Director and writer Dan Fogelman (“This Is Us”) examines the perils and rewards of everyday life in a multigenerational saga featuring an international ensemble including Oscar Isaac, Olivia Wilde, Antonio Banderas, Annette Bening, Olivia Cooke, Sergio Peris- Mencheta, Laia Costa, Alex Monner and Mandy Patinkin. Set in New York City and Carmona, Spain, Life Itself celebrates the human condition and all of its complications with humor, poignancy and love.

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